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How Long Does It Take For Bedinvetmab To Clear From The Body and What Support Helps?

A common question from many pet parents seeing side-effects in their dogs following the administration of Librela is 'How long will it take to clear from the body and is there anything I can do to help in the meantime?''

According to the European Medicines Agency's (EMA) public assessment report, the half-life of Bedinvetmab (anti-Nerve Growth Factor) in dogs is approximately 10 to 12 days.

This means that the concentration of the drug in the body will roughly halve every 10 to 12 days.

Based on this, the graph below shows the percentage decline of Librela in the system over 60 days*. 

*NOTEthis is an estimation however, as a particular dog's health, age, metabolism, the presence of medical conditions and other factors can all influence the actual clearance time.



How Does The Body Eliminate Bedinvetmab?

Monoclonal antibodies - unlike small molecule drugs - are primarily broken down by macrophages in the reticuloendothelial (RE) system. 

These specialised cells of the immune system, found in the liver, lymph nodes, spleen and lymphoid tissue of the gut, use proteolytic enzymes to reduce antibodies to peptides and amino acids, which can be recycled by the body or excreted. 

This process is generally much slower than the breakdown of small drugs by the liver, which Bedinvetmab takes longer to decline to a level which has no discernible effect.


How Can The Body Be Supported During This Time?

At present, there is no practical way to speed up the degradation of Bedinvetmab because it depends on the normal, healthy functioning of immune system mechanisms.

It is possible however, to reduce the risk of potential side-effects and / or help the body cope more successfully with adverse events which do arise, by providing nutritional support, as follows:


1.  Detoxification Support (2 - 3 drops 3 times daily on a teaspoon of fresh food - not kibble - for 2 weeks on and 2 weeks off) helps maintain normal liver, kidney and bowel function, which can be disturbed by anti-NGF.

2.  Immunity support normal immune system function, which is important for the normal clearance of Librela from the body.

After 3 - 4 days, if the stools remain well-formed also give Vitality and Lion's Mane.

3.  Vitality provides a rich supply of antioxidants which have anti-inflammatory properties, it also provides nutrients important for tissue regeneration and repair.

4.  Lion's Mane is reported to stimulate Nerve Growth Factor production which may reduce the duration of any anti-NGD induced adverse reactions that occur. (Enter vincethevet15 at checkout on Time Health's website to receive 15 % discount.)


NOTE

It is important to introduce the above supplements stepwise and in small amounts to begin with, and increase gradually as long as stools remain well-formed until the suggested daily amount is reached. This allows the digestive tract to adapt at a comfortable pace to an enriched, nutrient dense support diet.